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  Genebrush:

A gene delivery device and gene delivery method was developed at the Mayo Clinic.

  • This invention has been informally referred to as "The Genebrush"
  • USPTO Patent 6,821,264

The reported advantages of this technology and technique are the enhanced accuracy and efficiency of direct gene-based "vector" application via a brush device and action.

Publications regarding this particular technique/technology:

  • The original work was carried out by researchers in Minnesota:
    • VG Khurana, DA Weiler, TA Witt, LA Smith, LS Kleppe, JE Parisi, RD Simari, T O’Brien, SJ Russell, ZS Katusic. A direct mechanical method for accurate and efficient adenoviral vector delivery to tissues. Gene Therapy. Volume 10. Pages 443-452. 2003.
  • Independent validation of was carried out by researchers in the Netherlands and at Johns Hopkins in Baltimore:
    • JI Rotmans, HJ Verhagen, E Velema, DP de Kleijn, M van den Heuvel, JJ Kastelein, G Pasterkamp, ES Stroes. Local overexpression of C-type natriuretic peptide ameliorates vascular adaptation of porcine hemodialysis grafts. Kidney International. Volume 65. Pages 1897-1905. 2004.
    • K Kikuchi, AD McDonald, T Sasano, JK Donahue JK. Targeted modification of atrial electrophysiology by homogeneous transmural atrial gene transfer. Circulation. Volume 111. Pages 264-270. 2005.
  • A review article related to the original work:
    • VG Khurana, FB Meyer: Translational paradigms in cerebrovascular gene transfer. Journal of Cerebral Blood Flow and Metabolism. Volume 23. Pages 1251-1962. 2003.

     

     

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