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A gene delivery device and gene delivery method was developed at the Mayo Clinic.
- This invention has been informally referred to as "The Genebrush"
- USPTO Patent 6,821,264
The reported advantages of this technology and technique are the enhanced accuracy and efficiency of direct gene-based "vector" application via a brush device and action.
Publications regarding this particular technique/technology:
- The original work was carried out by researchers in Minnesota:
- VG Khurana, DA Weiler, TA Witt, LA Smith, LS Kleppe, JE Parisi, RD Simari, T O’Brien, SJ Russell, ZS Katusic. A direct mechanical method for accurate and efficient adenoviral vector delivery to tissues. Gene Therapy. Volume 10. Pages 443-452. 2003.
- Independent validation of was carried out by researchers in the Netherlands and at Johns Hopkins in Baltimore:
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- JI Rotmans, HJ Verhagen, E Velema, DP de Kleijn, M van den Heuvel, JJ Kastelein, G Pasterkamp, ES Stroes. Local overexpression of C-type natriuretic peptide ameliorates vascular adaptation of porcine hemodialysis grafts. Kidney International. Volume 65. Pages 1897-1905. 2004.
- K Kikuchi, AD McDonald, T Sasano, JK Donahue JK. Targeted modification of atrial electrophysiology by homogeneous transmural atrial gene transfer. Circulation. Volume 111. Pages 264-270. 2005.
- A review article related to the original work:
- VG Khurana, FB Meyer: Translational paradigms in cerebrovascular gene transfer. Journal of Cerebral Blood Flow and Metabolism. Volume 23. Pages 1251-1962. 2003.
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